Triggerable tough hydrogels for gastric resident dosage forms

• Main Authors: Liu, Jinyao (Contributor), Pang, Yan (Contributor), Zhang, Shiyi (Contributor), Cleveland, Cody (Contributor), Yin, Xiaolei (Contributor), Booth, Lucas (Contributor), Lin, Jiaqi (Contributor), Lee, Young-Ah (Contributor), Mazdiyasni, Hormoz (Contributor), Saxton, Sarah (Contributor), Kirtane, Ameya (Contributor), von Erlach, Thomas C (Contributor), Rogner, Jaimie L (Contributor), Langer, Robert S (Contributor), Traverso, Carlo Giovanni (Contributor)
• Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
• Format: Article
• Language: English
• Published: Nature Publishing Group, 2017-12-11T19:38:40Z.
• Subjects: Article
• Online Access: Get fulltext

Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ensure prolonged gastric residence, have the mechanical integrity to withstand the forces associated with gastrointestinal motility, be triggerable to address any side effects, and be drug loadable and release drug over a prolonged period of time. Materials that have been primarily utilized for these applications have been largely restricted to thermoplastics and thermosets. Here we describe a novel set of materials, triggerable tough hydrogels, meeting all these requirement, supported by evaluation in a large animal model and ultimately demonstrate the potential of triggerable tough hydrogels to serve as prolonged gastric resident drug depots. Triggerable tough hydrogels may be applied in myriad of applications, including bariatric interventions, drug delivery, and tissue engineering.
Bill & Melinda Gates Foundation (Grant OPP1096734)
Bill & Melinda Gates Foundation (Grant OPP1139927)
National Institutes of Health (U.S.) (Grant EB000244)