Hypoxia as a therapy for mitochondrial disease

Hypoxia as a therapy for mitochondrial disease

Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia...

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Main Authors: Jain, I. H. (Author), Zazzeron, L. (Author), Goli, R. (Author), Alexa, K. (Author), Schatzman-Bone, S. (Author), Dhillon, H. (Author), Goldberger, O. (Author), Peng, J. (Author), Goessling, W. (Author), Zapol, W. M. (Author), Mootha, V. K. (Author), Shalem, Ophir (Contributor), Sanjana, Neville E (Contributor), Zhang, Feng (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-12-12T17:11:56Z.
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