Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis
Background--Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which...
Main Authors: | Budatha, Madhusudhan (Author), Zhang, Jiasheng (Author), Zhuang, Zhen W. (Author), Yun, Sanguk (Author), Dahlman, James E. (Author), Schwartz, Martin A. (Author), Anderson, Daniel Griffith (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Heart Association,
2018-05-02T17:02:47Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling
by: Madhusudhan Budatha, et al.
Published: (2021-09-01) -
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
by: Yun, Sanguk, et al.
Published: (2017) -
Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk
by: Deenadayalan Bakthavatsalam, et al.
Published: (2021-01-01) -
Unravelling the interactions of the beta7 integrin cytoplasmic domain
by: Chan, Yih-Chih
Published: (2010) -
The hydromechanics in arteriogenesis
by: Tianqi Ma, et al.
Published: (2020-09-01)