Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells

Production of the pro-inflammatory cytokine IL-12 by innate phagocytes drives the differentiation of IFN-γ-producing effector T cells during Toxoplasma gondii infection. However, the role of IL-12 in the regulation of memory CD8+ T cell differentiation and function during murine toxoplasmosis is unc...

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Bibliographic Details
Main Authors: Wilson, Douglas C. (Author), Grotenbreg, Gijsbert M. (Author), Liu, Kenian (Author), Zhao, Yanlin (Author), Frickel, Eva-Maria (Author), Gubbels, Marc-Jan (Author), Yap, George S. (Author), Ploegh, Hidde (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Public Library of Science (PLoS), 2018-06-11T14:52:23Z.
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