Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells
Production of the pro-inflammatory cytokine IL-12 by innate phagocytes drives the differentiation of IFN-γ-producing effector T cells during Toxoplasma gondii infection. However, the role of IL-12 in the regulation of memory CD8+ T cell differentiation and function during murine toxoplasmosis is unc...
Main Authors: | Wilson, Douglas C. (Author), Grotenbreg, Gijsbert M. (Author), Liu, Kenian (Author), Zhao, Yanlin (Author), Frickel, Eva-Maria (Author), Gubbels, Marc-Jan (Author), Yap, George S. (Author), Ploegh, Hidde (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS),
2018-06-11T14:52:23Z.
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Subjects: | |
Online Access: | Get fulltext |
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