Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

Background Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, functional studies of these subsets at scale require faithful in vitro models of i...

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Main Authors: Szucs, Matthew J (Author), Ammendolia, Dustin A (Author), MacMullan, Melanie A (Author), Rakoff-Nahoum, Seth (Author), Mead, Benjamin Elliott (Contributor), Ordovas-Montanes, Jose Manuel (Contributor), Braun, Alexandra Provost (Contributor), Levy, Lauren (Contributor), Saluja, Prerna Bhargava (Contributor), Yin, Xiaolei (Contributor), Hughes, Travis K. (Contributor), Wadsworth, Marc Havens (Contributor), Ahmad, Rushdy (Contributor), Carr, Steven A (Contributor), Langer, Robert S (Contributor), Collins, James J. (Contributor), Shalek, Alexander K (Contributor), Karp, Jeffrey Michael (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Karp, Jeffrey (Contributor)
Format: Article
Language:English
Published: Biomed Central Ltd, 2018-06-12T19:08:18Z.
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