A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis

A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis

Oxetanocin A (OXT-A) is a potent antitumour, antiviral and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster that contains four genes: oxsA, oxsB, oxrA and oxrB. Here we show that both the oxsA and oxsB genes are required for the produc...

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Bibliographic Details
Main Authors: Zhong, Aoshu (Author), Sun, He G. (Author), Liu, Hung-wen (Author), Rabb, Jennifer (Contributor), Drennan, Catherine L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-06-15T18:03:53Z.
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