Gamete Formation Resets the Aging Clock in Yeast

• Main Authors: Unal, Elcin (Contributor), Amon, Angelika B (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
• Format: Article
• Language: English
• Published: Cold Spring Harbor Laboratory, 2018-06-19T13:02:06Z.
• Subjects: Article
• Online Access: Get fulltext

Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
National Institutes of Health (U.S.) (grant GM62207)