The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial-mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summa...
Main Authors: | , , |
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Other Authors: | , |
Format: | Article |
Language: | English |
Published: |
Informa UK Limited,
2018-06-22T17:13:00Z.
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Subjects: | |
Online Access: | Get fulltext |
Summary: | In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial-mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR National Science Foundation (U.S.) (Grant 1122374) |
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