The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition

In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial-mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summa...

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Bibliographic Details
Main Authors: Feng, Yu-xiong (Author), Sokol, Ethan Samuel (Contributor), Gupta, Piyush (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Informa UK Limited, 2018-06-22T17:13:00Z.
Subjects:
Online Access:Get fulltext
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100 1 0 |a Feng, Yu-xiong  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biology  |e contributor 
100 1 0 |a Koch Institute for Integrative Cancer Research at MIT  |e contributor 
100 1 0 |a Sokol, Ethan Samuel  |e contributor 
100 1 0 |a Gupta, Piyush  |e contributor 
700 1 0 |a Sokol, Ethan Samuel  |e author 
700 1 0 |a Gupta, Piyush  |e author 
245 0 0 |a The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition 
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856 |z Get fulltext  |u http://hdl.handle.net/1721.1/116526 
520 |a In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial-mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR 
520 |a National Science Foundation (U.S.) (Grant 1122374) 
655 7 |a Article 
773 |t Molecular & Cellular Oncology