Designing helical peptide inhibitors of protein-protein interactions
Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide desi...
| Main Authors: | , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier,
2018-06-26T18:05:47Z.
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| Subjects: | |
| Online Access: | Get fulltext |
| Summary: | Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and give examples of peptide design studies targeting coiled-coil transcription factors, Bcl-2 family proteins, MDM2/MDMX, and HIV gp41, among other targets. National Institute of General Medical Sciences (U.S.) (Award GM067681) National Institute of General Medical Sciences (U.S.) (Award GM110048) National Institute of General Medical Sciences (U.S.) (Award GM084181) |
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