Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF)≥5% and low-frequency variants (0.5≤MAF&l...

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Bibliographic Details
Main Authors: Mitt, Mario (Author), Kals, Mart (Author), Pärn, Kalle (Author), Ripatti, Samuli (Author), Morris, Andrew P (Author), Metspalu, Andres (Author), Esko, Tõnu (Author), Mägi, Reedik (Author), Palta, Priit (Author), Gabriel, Stacey (Contributor), Lander, Eric Steven (Contributor), Palotie, Aarno (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-06-29T16:08:14Z.
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