Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF)≥5% and low-frequency variants (0.5≤MAF&l...
Main Authors: | Mitt, Mario (Author), Kals, Mart (Author), Pärn, Kalle (Author), Ripatti, Samuli (Author), Morris, Andrew P (Author), Metspalu, Andres (Author), Esko, Tõnu (Author), Mägi, Reedik (Author), Palta, Priit (Author), Gabriel, Stacey (Contributor), Lander, Eric Steven (Contributor), Palotie, Aarno (Contributor) |
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Other Authors: | Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2018-06-29T16:08:14Z.
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Subjects: | |
Online Access: | Get fulltext |
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