Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in which cancer stem cells (CSCs) can drive tumour growth and give rise to differentiated progeny. Yet, unbiased...

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Main Authors: Tirosh, Itay (Author), Venteicher, Andrew S. (Author), Hebert, Christine (Author), Escalante, Leah E. (Author), Patel, Anoop P. (Author), Yizhak, Keren (Author), Fisher, Jonathan M. (Author), Rodman, Christopher (Author), Mount, Christopher (Author), Filbin, Mariella G. (Author), Neftel, Cyril (Author), Desai, Niyati (Author), Nyman, Jackson (Author), Izar, Benjamin (Author), Luo, Christina C. (Author), Francis, Joshua M. (Author), Patel, Aanand A. (Author), Onozato, Maristela L. (Author), Riggi, Nicolo (Author), Livak, Kenneth J. (Author), Gennert, Dave (Author), Satija, Rahul (Author), Nahed, Brian V. (Author), Curry, William T. (Author), Martuza, Robert L. (Author), Mylvaganam, Ravindra (Author), Iafrate, A. John (Author), Frosch, Matthew P. (Author), Rivera, Miguel N. (Author), Getz, Gad (Author), Rozenblatt-Rosen, Orit (Author), Cahill, Daniel P. (Author), Monje, Michelle (Author), Bernstein, Bradley E. (Author), Louis, David N. (Author), Suvà, Mario L. (Author), Golub, Todd (Contributor), Regev, Aviv (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-03T14:38:08Z.
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Online Access:Get fulltext

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