KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are a key input to this system, and act through the Rag GTPases to promote...

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Bibliographic Details
Main Authors: Shen, Kuang (Author), Petri, Sabrina (Author), Abu-Remaileh, Monther (Author), Frankel, Wayne N. (Author), Wolfson, Rachel Laura (Contributor), Chantranupong, Lynne (Contributor), Wyant, Gregory Andrew (Contributor), Gu, Xin (Contributor), Orozco Segrera, Jose (Contributor), Condon, Kendall Janine (Contributor), Kedir, Jibril Fetu (Contributor), Scaria, Sonia M. (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-03T18:34:16Z.
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