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01503 am a22002293u 4500 |
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116936 |
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|a dc
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|a Vander Heiden, Matthew G.
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Vander Heiden, Matthew G.
|e contributor
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|a DeBerardinis, Ralph J.
|e author
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|a Understanding the Intersections between Metabolism and Cancer Biology
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| 260 |
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|b Elsevier BV,
|c 2018-07-12T16:28:26Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/116936
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|a Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
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|a National Cancer Institute (U.S.) (CA168653)
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|a National Cancer Institute (U.S.) (CA201276)
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|a Lustgarten Foundation
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|a Howard Hughes Medical Institute (Faculty Scholars Award)
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|a Article
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|t Cell
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