Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors is incompletely understood. Amino acids are essent...

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Main Authors: Kellersberger, Katherine A (Author), Stall, Brian K (Author), Stephanopoulos, Gregory (Author), Bar-Sagi, Dafna (Author), Han, Jongyoon (Author), Rabinowitz, Joshua D (Author), Davidson, Shawn M (Contributor), Jonas, Oliver H. (Contributor), Keibler, Mark Andrew (Contributor), Hou, Han Wei (Contributor), Luengo, Alba (Contributor), Mayers, Jared R. (Contributor), Wyckoff, Jeffrey (Contributor), Del Rosario, Amanda M (Contributor), Whitman, Matthew A (Contributor), Condon, Kendall Janine (Contributor), Lammers, Alex A (Contributor), Langer, Robert S (Contributor), Vander Heiden, Matthew G. (Contributor), Cima, Michael J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Cima, Michael J (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-12T18:36:26Z.
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