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|a Marzen, Sarah E.
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|a Massachusetts Institute of Technology. Department of Physics
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|a Marzen, Sarah E.
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|a Crutchfield, James P.
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|a Optimized bacteria are environmental prediction engines
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|b American Physical Society,
|c 2018-07-24T13:43:54Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/117060
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|a Experimentalists observe phenotypic variability even in isogenic bacteria populations. We explore the hypothesis that in fluctuating environments this variability is tuned to maximize a bacterium's expected log-growth rate, potentially aided by epigenetic (all inheritable nongenetic) markers that store information about past environments. Crucially, we assume a time delay between sensing and action, so that a past epigenetic marker is used to generate the present phenotypic variability. We show that, in a complex, memoryful environment, the maximal expected log-growth rate is linear in the instantaneous predictive information-the mutual information between a bacterium's epigenetic markers and future environmental states. Hence, under resource constraints, optimal epigenetic markers are causal states-the minimal sufficient statistics for prediction-or lossy approximations thereof. We propose new theoretical investigations into and new experiments on bacteria phenotypic bet-hedging in fluctuating complex environments.
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|a Templeton Foundation (Grant 52095)
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|a Foundational Questions Institute (Grant FQXi-RFP-1609)
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|a United States. Army Research Office (Contract W911NF-13-1-0390)
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|a en
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|a Article
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|t Physical Review E
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