Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease
The HDL receptor SR-BI mediates the transfer of cholesteryl esters from HDL to cells and controls HDL abundance and structure. Depending on the genetic background, loss of SR-BI causes hypercholesterolemia, anemia, reticulocytosis, splenomegaly, thrombocytopenia, female infertility, and fatal corona...
Main Authors: | Pal, Rinku (Author), Ke, Qingen (Author), Pihan, German A. (Author), Chitraju, Chandramohan (Author), Kang, Peter M. (Author), Kocher, Olivier (Author), Yesilaltay, Ayce (Contributor), Penman, Marsha L (Contributor), Wang, Li (Contributor), Krieger, Monty (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Krieger M (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Physiological Society,
2018-07-30T17:37:57Z.
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Subjects: | |
Online Access: | Get fulltext |
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