Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological applications. We recently developed a platform termed SHERLOCK (specific high-sensitivity enzymatic reporter unlocking) that combines isothermal preamplification with Cas13 to detect single molecules of RNA or...

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Bibliographic Details
Main Authors: Kellner, Max J. (Author), Gootenberg, Jonathan S (Contributor), Joung, Julia (Contributor), Collins, James J. (Contributor), Zhang, Feng (Contributor), Abudayyeh, Omar O. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Abudayyeh, Omar Osama (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2018-08-28T16:57:35Z.
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