HiGlass: web-based visual exploration and analysis of genome interaction maps

• Main Authors: Kerpedjiev, Peter (Author), Lekschas, Fritz (Author), McCallum, Chuck (Author), Dinkla, Kasper (Author), Strobelt, Hendrik (Author), Luber, Jacob M (Author), Ouellette, Scott B (Author), Azhir, Alaleh (Author), Kumar, Nikhil (Author), Hwang, Jeewon (Author), Lee, Soohyun (Author), Alver, Burak H (Author), Pfister, Hanspeter (Author), Park, Peter J (Author), Gehlenborg, Nils (Author), Luber, Jacob M. (Author), Ouellette, Scott B. (Author), Alver, Burak H. (Author), Mirny, Leonid A. (Author), Park, Peter J. (Author), Abdennur, Nezar Alexander (Contributor), Mirny, Leonid A (Contributor)
• Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
• Format: Article
• Language: English
• Published: BioMed Central, 2018-09-11T19:06:44Z.
• Subjects: Article
• Online Access: Get fulltext

We present HiGlass, an open source visualization tool built on web technologies that provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps alongside 1D genomic tracks, allowing users to combine various data types, synchronize multiple visualization modalities, and share fully customizable views with others. We demonstrate its utility in exploring different experimental conditions, comparing the results of analyses, and creating interactive snapshots to share with collaborators and the broader public. HiGlass is accessible online at http://higlass.io and is also available as a containerized application that can be run on any platform.
National Institutes of Health (U.S.) (U01 CA200059)
National Institutes of Health (U.S.) (R00 HG007583)
National Institutes of Health (U.S.) (U54 HG007963)