Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope
Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for co...
Main Authors: | Watanabe, Satoru (Author), Chan, Kuan Rong (Author), Huan, Jia (Author), Chionh, Yok Hian (Author), Raguram, Aditya (Author), McBee, Megan (Author), Ong, Eugenia Z. (Author), Gan, Esther S. (Author), Tan, Hwee Cheng (Author), Tyagi, Anu (Author), Bhushan, Shashi (Author), Lescar, Julien (Author), Vasudevan, Subhash G. (Author), Ooi, Eng Eong (Author), Tharakaraman, Kannan (Contributor), Subramanian, Vidya (Contributor), Quinlan, Devin Scott (Contributor), Sasisekharan, Ram (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2018-10-01T20:04:39Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
An inter-residue network model to identify mutational-constrained regions on the Ebola coat glycoprotein
by: Quinlan, Devin Scott, et al.
Published: (2017) -
Influenza Surveillance: 2014-2015 H1N1 "Swine"-Derived Influenza Viruses from India
by: Tharakaraman, Kannan, et al.
Published: (2017) -
Broadly Neutralizing Influenza Hemagglutinin Stem-Specific Antibody CR8020 Targets Residues that Are Prone to Escape due to Host Selection Pressure
by: Tharakaraman, Kannan, et al.
Published: (2015) -
Glycan-protein interactions in viral pathogenesis
by: Raman, Rahul, et al.
Published: (2018) -
Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides
by: Hia, Fabian, et al.
Published: (2015)