Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex - comprising DEPDC5, NPRL2 and NPRL3 - regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvati...
Main Authors: | , , , , , , , , , , |
---|---|
Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Springer Nature,
2018-11-05T12:46:12Z.
|
Subjects: | |
Online Access: | Get fulltext |