Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes

Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex - comprising DEPDC5, NPRL2 and NPRL3 - regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvati...

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Bibliographic Details
Main Authors: Shen, Kuang (Author), Bomaliyamu, Aimaiti (Author), Hong, Chuan (Author), Yu, Zhiheng (Author), Huang, Rick (Contributor), Brignole, Edward J (Contributor), Condon, Kendall Janine (Contributor), Valenstein, Max L. (Contributor), Chantranupong, Lynne (Contributor), Choe, Abigail D. (Contributor), Sabatini, David (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-11-05T12:46:12Z.
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