Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

mRNA has broad potential for treating diseases requiring protein expression. However, mRNA can also induce an immune response with associated toxicity. Replacement of uridine bases with pseudouridine has been postulated to modulate both mRNA immunogenicity and potency. Here, we explore the immune re...

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Bibliographic Details
Main Authors: Heartlein, Michael W. (Author), DeRosa, Frank (Author), Kauffman, Kevin John (Contributor), Mir, Faryal (Contributor), Jhunjhunwala, Siddharth (Contributor), Kaczmarek, James Cliff (Contributor), Hurtado, Juan E. (Contributor), Yang, Jung H (Contributor), Webber, Matthew (Contributor), Kowalski, Piotr S (Contributor), Anderson, Daniel Griffith (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-12-07T20:38:44Z.
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