Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition
Introduction: Targeted cancer therapeutics have demonstrated more limited clinical efficacy than anticipated, due to both intrinsic and acquired drug resistance. Underlying mechanisms have been largely attributed to genetic changes, but a substantial proportion of resistance observations remain unex...
Main Authors: | Meyer, Aaron S. (Author), Claas, Allison Mary (Contributor), Atta, Lyla H. (Contributor), Gordonov, Simon (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer US,
2018-12-13T21:44:56Z.
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Subjects: | |
Online Access: | Get fulltext |
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