How many human proteoforms are there?

Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level...

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Main Authors: Aebersold, Ruedi (Author), Agar, Jeffrey N (Author), Amster, I Jonathan (Author), Baker, Mark S (Author), Bertozzi, Carolyn R (Author), Boja, Emily S (Author), Costello, Catherine E (Author), Cravatt, Benjamin F (Author), Fenselau, Catherine (Author), Garcia, Benjamin A (Author), Ge, Ying (Author), Gunawardena, Jeremy (Author), Hendrickson, Ronald C (Author), Hergenrother, Paul J (Author), Huber, Christian G (Author), Ivanov, Alexander R (Author), Jensen, Ole N (Author), Jewett, Michael C (Author), Kelleher, Neil L (Author), Krogan, Nevan J (Author), Larsen, Martin R (Author), Loo, Joseph A (Author), Ogorzalek Loo, Rachel R (Author), Lundberg, Emma (Author), MacCoss, Michael J (Author), Mallick, Parag (Author), Mootha, Vamsi K (Author), Mrksich, Milan (Author), Muir, Tom W (Author), Patrie, Steven M (Author), Pesavento, James J (Author), Pitteri, Sharon J (Author), Rodriguez, Henry (Author), Saghatelian, Alan (Author), Sandoval, Wendy (Author), Schlüter, Hartmut (Author), Sechi, Salvatore (Author), Slavoff, Sarah A (Author), Smith, Lloyd M (Author), Snyder, Michael P (Author), Thomas, Paul M (Author), Uhlén, Mathias (Author), Van Eyk, Jennifer E (Author), Vidal, Marc (Author), Walt, David R (Author), White, Forest M (Author), Williams, Evan R (Author), Wohlschlager, Therese (Author), Wysocki, Vicki H (Author), Yates, Nathan A (Author), Young, Nicolas L (Author), Zhang, Bing (Author), Kiessling, Laura L (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2019-03-15T13:22:11Z.
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