Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation

We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues from the Genotype-Tissue Expression project and genome-wide association study data. About 60% of known trait-associated loci are in linkage disequilibrium with a cis-eQTL, over half of which were not found in pre...

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Main Authors: Gamazon, Eric R. (Author), Segrè, Ayellet V. (Author), van de Bunt, Martijn (Author), Wen, Xiaoquan (Author), Xi, Hualin S. (Author), Hormozdiari, Farhad (Author), Ongen, Halit (Author), Konkashbaev, Anuar (Author), Derks, Eske M. (Author), Aguet, François (Author), Quan, Jie (Author), GTEx Consortium (Author), Nicolae, Dan L. (Author), Eskin, Eleazar (Author), Kamvysselis, Manolis (Author), Getz, Gad (Author), McCarthy, Mark I. (Author), Dermitzakis, Emmanouil T. (Author), Cox, Nancy J. (Author), Ardlie, Kristin G. (Author)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2019-06-07T21:12:22Z.
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