HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease
Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time b...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Biomed Central Ltd.,
2019-06-10T19:00:57Z.
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| Subjects: | |
| Online Access: | Get fulltext |
| Summary: | Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant. Keywords: Vioxx, Glycol Diacrylate, Genotype Pool, Tissue Module, Polyethylene Glycol Diacrylate National Institutes of Health (U.S.) (Grant UH2 EB017103) |
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