HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time b...

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Bibliographic Details
Main Authors: Vunjak-Novakovic, Gordana V (Author), Bhatia, Sangeeta N (Author), Chen, Christopher (Author), Hirschi, Karen (Author)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: Biomed Central Ltd., 2019-06-10T19:00:57Z.
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Online Access:Get fulltext
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100 1 0 |a Vunjak-Novakovic, Gordana V  |e author 
100 1 0 |a Harvard University-  |e contributor 
700 1 0 |a Bhatia, Sangeeta N  |e author 
700 1 0 |a Chen, Christopher  |e author 
700 1 0 |a Hirschi, Karen  |e author 
245 0 0 |a HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease 
260 |b Biomed Central Ltd.,   |c 2019-06-10T19:00:57Z. 
856 |z Get fulltext  |u https://hdl.handle.net/1721.1/121236 
520 |a Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant. Keywords: Vioxx, Glycol Diacrylate, Genotype Pool, Tissue Module, Polyethylene Glycol Diacrylate 
520 |a National Institutes of Health (U.S.) (Grant UH2 EB017103) 
546 |a en 
655 7 |a Article 
773 |t Stem Cell Research & Therapy