In vitro evolution of enhanced RNA replicons for immunotherapy

In vitro evolution of enhanced RNA replicons for immunotherapy

Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identi...

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Bibliographic Details
Main Authors: Li, Yingzhong (Author), Teague, Brian Paul (Author), Su, Zhijun (Author), Porter, Ely (Author), Dobosh, Brian S (Author), Wagner, Tyler E (Author), Irvine, Darrell J (Author), Weiss, Ron (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-03-25T12:15:04Z.
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