3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture

• Main Authors: Kolewe, Martin E. (Author), Park, Hyoungshin (Author), Gray, Caprice (Author), Ye, Xiaofeng (Author), Langer, Robert (Author), Freed, Lisa E. (Author)
• Other Authors: Harvard University- (Contributor)
• Format: Article
• Language: English
• Published: Wiley, 2020-04-07T19:51:42Z.
• Subjects: Article
• Online Access: Get fulltext

Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ©2013
National Heart, Lung and Blood Institute (award: 1-R01-HL107503)