3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture

3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture

Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fi...

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Bibliographic Details
Main Authors: Kolewe, Martin E. (Author), Park, Hyoungshin (Author), Gray, Caprice (Author), Ye, Xiaofeng (Author), Langer, Robert (Author), Freed, Lisa E. (Author)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: Wiley, 2020-04-07T19:51:42Z.
Subjects:
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Online Access:Get fulltext
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520 |a Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ©2013 
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773 |t Advanced materials 

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