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|a dc
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|a Mihaylova, Maria M.
|e author
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|a Whitehead Institute for Biomedical Research
|e contributor
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Cheng, Chia-Wei
|e author
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|a Cao, Amanda Q.
|e author
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|a Tripathi, Surya
|e author
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|a Mana, Miyeko D.
|e author
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|a Bauer-Rowe, Khristian E.
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|a Abu-Remaileh, Monther
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|a Clavain, Laura
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|a Erdemir, Aysegul
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|a Lewis, Caroline A.
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|a Freinkman, Elizaveta
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|a Huang, Yanmei
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|a Bell, George W.
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|a Sabatini, David M.
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|a Yilmaz, Ömer H.
|e author
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|a Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
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|b Elsevier BV,
|c 2020-04-17T13:27:03Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/124714
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|a Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration. Mihaylova et al. show that short-term fasting promotes intestinal stem and progenitor cell function in young and aged mice by inducing a robust fatty acid oxidation (FAO) program. PPARδ agonists emulate these effects, showing that fatty acid metabolism has positive effects on young and old ISCs.
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|a National Institutes of Health (U.S.) (Grant R00 AG045144)
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|a National Institutes of Health (U.S.) (Grant R01CA211184)
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|a National Institutes of Health (U.S.) (Grant R01CA034992)
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|a National Institutes of Health (U.S.) (Grant CA103866)
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|a National Institutes of Health (U.S.) (K99 Pathway to Independence award K99AG054760)
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|a en
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|a Molecular Medicine
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|a Genetics
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|a Cell Biology
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|a Article
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|t 10.1016/j.stem.2018.04.001
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|t Cell Stem Cell
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