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125012 |
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|a dc
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|a Regev, Aviv
|e author
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|a Massachusetts Institute of Technology. Department of Biology
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
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|b Elsevier BV,
|c 2020-05-05T15:27:04Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/125012
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|a Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
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|a en
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|a Developmental Biology
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|a Article
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|t 10.1016/j.devcel.2019.03.001
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773 |
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|t Developmental Cell
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