Antimalarial activity of primaquine operates via a two-step biochemical relay

Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70 years ago, its mode of action is unclear. Here, we demonstrate that hydroxylated-PQ metabolites (OH-PQm) are responsible for efficacy against liver and sexual transmission stages of Plasmodium falciparum. The antim...

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Bibliographic Details
Main Authors: March, Sandra (Author), Miller, Alex B. (Author), Bhatia, Sangeeta N. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-12T14:29:51Z.
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