DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro
5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET) family enzymes, which are -ketoglutarate (-KG)/F...
Main Authors: | Bian, Ke (Author), Lenz, Stefan A P (Author), Tang, Qi (Author), Chen, Fangyi (Author), Qi, Rui (Author), Jost, Marco (Author), Drennan, Catherine L (Author), Essigmann, John M (Author), Wetmore, Stacey D (Author), Li, Deyu (Author) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Oxford University Press (OUP),
2020-05-12T15:37:29Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.
by: Daniel Gackowski, et al.
Published: (2015-01-01) -
Sequence Dependent Repair of 1,<i>N</i><sup>6</sup>-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB
by: Rui Qi, et al.
Published: (2021-08-01) -
Dysregulation and prognostic potential of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) levels in prostate cancer
by: Tine Maj Storebjerg, et al.
Published: (2018-08-01) -
Genome wide profiling of 5-formylcytosine and 5-carboxylcytosine in melanoma
by: Rabidou, Kimberlie Ann Marques
Published: (2016) -
Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
by: Anna Chentsova, et al.
Published: (2014-01-01)