A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication
When DNA is unwound during replication, it becomes overtwisted and forms positive supercoils in front of the translocating DNA polymerase. Unless removed or dissipated, this superhelical tension can impede replication elongation. Topoisomerases, including gyrase and topoisomerase IV in bacteria, are...
Main Authors: | Guo, Monica S (Author), Haakonsen, Diane Laure (Author), Zeng, Wenjie (Author), Schumacher, Maria A. (Author), Laub, Michael T (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier BV,
2020-05-15T14:33:02Z.
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Subjects: | |
Online Access: | Get fulltext |
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