Neurons regulate synaptic strength through homeostatic scaling of active zones

• Main Authors: Cunningham, Karen L (Author), Littleton, J. Troy (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
• Format: Article
• Language: English
• Published: Rockefeller University Press, 2020-05-21T18:41:59Z.
• Subjects: Article
• Online Access: Get fulltext

How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size.
National Institutes of Health (U.S.) (Grant NS40296)
National Institutes of Health (U.S.) (Grant MH104536)
National Institutes of Health (U.S.) (Predoctoral Training Grant T32GM007287)