Neurons regulate synaptic strength through homeostatic scaling of active zones

How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite...

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Bibliographic Details
Main Authors: Cunningham, Karen L (Author), Littleton, J. Troy (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2020-05-21T18:41:59Z.
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Online Access:Get fulltext
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100 1 0 |a Cunningham, Karen L  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biology  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences  |e contributor 
100 1 0 |a Picower Institute for Learning and Memory  |e contributor 
700 1 0 |a Littleton, J. Troy  |e author 
245 0 0 |a Neurons regulate synaptic strength through homeostatic scaling of active zones 
260 |b Rockefeller University Press,   |c 2020-05-21T18:41:59Z. 
856 |z Get fulltext  |u https://hdl.handle.net/1721.1/125386 
520 |a How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size. 
520 |a National Institutes of Health (U.S.) (Grant NS40296) 
520 |a National Institutes of Health (U.S.) (Grant MH104536) 
520 |a National Institutes of Health (U.S.) (Predoctoral Training Grant T32GM007287) 
546 |a en 
655 7 |a Article 
773 |t 10.1083/JCB.201903065 
773 |t The Journal of cell biology