Thiazolidin-5-imine Formation as a Catalyst-Free Bioorthogonal Reaction for Protein and Live Cell Labeling

A previously undescribed reaction involving the formation of a thiazolidin-5-imine linkage was developed for bio-conjugation. Being highly specific and operating in aqueous media, this simple condensation reaction is used to chemoselectively label peptides, proteins and living cells under physiologi...

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Bibliographic Details
Main Authors: Bi, Xiaobao (Author), Yin, Juan (Author), Rao, Chang (Author), Balamkundu, Seetharamsing (Author), Zhang, Dingpeng (Author), Dedon, Peter C (Author), Liu, Chuan-Fa (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Singapore-MIT Alliance in Research and Technology (SMART) (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2020-06-19T21:12:56Z.
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