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125954 |
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|a dc
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|a Fu, Wai Chung
|e author
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Jamison, Timothy F
|e author
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|a Modular continuous flow synthesis of imatinib and analogues
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|b American Chemical Society (ACS),
|c 2020-06-23T19:37:48Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/125954
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|a A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.
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|a DARPA (contract no. ARO W911NF-16-2-0023)
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|a en
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|a Article
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|t 10.1021/ACS.ORGLETT.9B02259
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| 773 |
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|t Organic Letters
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