Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene expression remains unclear, largely because past studies using native and engineered sequences had insufficient scale. Here, we measure the expression output of >100 million synthetic yeast promoter sequences th...

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Bibliographic Details
Main Authors: de Boer, Carl G (Author), Vaishnav, Eeshit Dhaval (Author), Sadeh, Ronen (Author), Abeyta, Esteban Luis (Author), Friedman, Nir (Author), Regev, Aviv (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-06-25T17:07:04Z.
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