IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development

IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development

Regulatory T cells (Tregs) can impair anti-tumor immune responses and are associated with poor prognosis in multiple cancer types. Tregs in human tumors span diverse transcriptional states distinct from those of peripheral Tregs, but their contribution to tumor development remains unknown. Here, we...

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Main Authors: Li, Amy (Author), Herbst, Rebecca H. (Author), Canner, David Allen (Author), Schenkel, Jason (Author), Smith, Olivia C. (Author), Kim, Jonathan Y. (Author), Hillman, Michelle (Author), Bhutkar, Arjun (Author), Cuoco, Michael S. (Author), Rappazzo, C. Garrett (Author), Rogers, Patricia (Author), Dang, Celeste (Author), Jerby-Arnon, Livnat (Author), Rozenblatt-Rosen, Orit (Author), Cong, Le (Author), Birnbaum, Michael E (Author), Regev, Aviv (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-06-26T20:09:45Z.
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