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01314 am a22002173u 4500 |
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126008 |
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|a dc
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|a Ichikawa, Saki
|e author
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Dai, Xi-Jie
|e author
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|a Buchwald, Stephen Leffler
|e author
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|a Regio- and Enantioselective Synthesis of 1,2-Diamine Derivatives by Copper-Catalyzed Hydroamination
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|b American Chemical Society (ACS),
|c 2020-06-29T13:28:45Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/126008
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|a A highly regio- and enantioselective synthesis of 1,2-diamine derivatives from γ-substituted allylic pivalamides using copper-catalyzed hydroamination is reported. The N-pivaloyl group is essential, in both facilitating the hydrocupration step and suppressing an unproductive β-elimination from the alkylcopper intermediate. This approach enables an efficient construction of chiral differentially protected vicinal diamines under mild conditions with broad functional group tolerance. ©2019 American Chemical Society.
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|a National Institute of Health (R35-GM122483)
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|a National Institute of Health (R01-GM58160)
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|a NIH (Grant no. GM58160-17S1)
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|a en
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|a Article
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|t Organic Letters
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