Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy

Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy

The combined inhibition of histone deacetylases (HDAC) and the proteins of the bromodomain and extraterminal (BET) family have recently shown therapeutic efficacy against melanoma, pancreatic ductal adenocarcinoma, testicular, and lymphoma cancers in murine studies. However, in such studies, the rol...

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Main Authors: Badamchi-Zadeh, Alexander (Author), Moynihan, Kelly Dare (Author), Larocca, Rafael A. (Author), Aid, Malika (Author), Provine, Nicholas M. (Author), Iampietro, M. Justin (Author), Kinnear, Ekaterina (Author), Penaloza-MacMaster, Pablo (Author), Abbink, Peter (Author), Blass, Eryn (Author), Tregoning, John S. (Author), Irvine, Darrell J (Author), Barouch, Dan H. (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association of Immunologists, 2020-07-17T19:40:19Z.
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