A once-a-month oral contraceptive

• Main Authors: Kirtane, Ameya R. (Author), Hua, Tiffany (Author), Hayward, Alison (Author), Wahane, Aniket Vijay (Author), Lopes, Aaron (Author), Bensel, Taylor (Author), Brooks, Sierra (Author), Gwynne, Declan (Author), Wainer, Jacob (Author), Collins, Joy (Author), Tamang, Siid (Author), Langer, Robert (Author), Traverso, Giovanni (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
• Format: Article
• Language: English
• Published: American Association for the Advancement of Science (AAAS), 2020-08-26T12:46:28Z.
• Subjects: Article
• Online Access: Get fulltext

Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.
Bill & Melinda Gates Foundation (Grant OPP1139927)