Total Synthesis of (±)-Sceptrin

Total Synthesis of (±)-Sceptrin

A four-step synthesis of the dimeric pyrrole-imidazole alkaloid sceptrin is reported. The brevity of the route is based on a simple solution developed for selective assembly of the cyclobutane core of the natural product. The photochemical intermolecular [2 + 2] dimerization of a useful hymenidin su...

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Bibliographic Details
Main Authors: Nguyen, Long V. (Author), Jamison, Timothy F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2020-10-02T12:58:29Z.
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Online Access:Get fulltext
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100 1 0 |a Nguyen, Long V.  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
700 1 0 |a Jamison, Timothy F  |e author 
245 0 0 |a Total Synthesis of (±)-Sceptrin 
260 |b American Chemical Society (ACS),   |c 2020-10-02T12:58:29Z. 
856 |z Get fulltext  |u https://hdl.handle.net/1721.1/127790 
520 |a A four-step synthesis of the dimeric pyrrole-imidazole alkaloid sceptrin is reported. The brevity of the route is based on a simple solution developed for selective assembly of the cyclobutane core of the natural product. The photochemical intermolecular [2 + 2] dimerization of a useful hymenidin surrogate enables direct entry to this enigmatic class of biologically active marine secondary metabolites. ©2020 American Chemical Society. 
520 |a Bill & Melinda Gates Foundation 
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655 7 |a Article 
773 |t Organic Letters 

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