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130387 |
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|a Akay, Leyla Anne
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|a Picower Institute for Learning and Memory
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|a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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|a Effenberger, Audrey H.
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|a Tsai, Li-Huei
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|a Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function
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|b Cold Spring Harbor Laboratory,
|c 2021-04-06T14:40:37Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/130387
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|a Oligodendrocyte precursor cells (OPCs) are not merely a transitory progenitor cell type, but rather a distinct and heterogeneous population of glia with various functions in the developing and adult central nervous system. In this review, we discuss the fate and function of OPCs in the brain beyond their contribution to myelination. OPCs are electrically sensitive, form synapses with neurons, support blood-brain barrier integrity, and mediate neuroinflammation. We explore how sex and age may influence OPC activity, and we review how OPC dysfunction may play a primary role in numerous neurological and neuropsychiatric diseases. Finally, we highlight areas of future research.
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|a National Institutes of Health (Grants RF1-AG062377, RF1-AG054012-01, U54HG008097, and UG3NS115064).
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|a Article
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|t Genes & Development
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