APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation
The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer's disease (AD). One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated pathology in neurons such as amyloid-β (Aβ) accumulatio...
Main Authors: | Lee, Se-In (Author), Jeong, Woojin (Author), Lim, Heejin (Author), Cho, Sukhee (Author), Lee, Hyein (Author), Jang, Yonghee (Author), Cho, Joonho (Author), Bae, Simsung (Author), Lin, Yuan-Ta (Author), Tsai, Li-Huei (Author), Moon, Dae Won (Author), Seo, Jinsoo (Author) |
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Format: | Article |
Language: | English |
Published: |
Elsevier BV,
2021-12-08T16:57:29Z.
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Subjects: | |
Online Access: | Get fulltext |
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